Modulation of N-methyl-D-aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.

N-Methyl-D-Aspartic Acid Receptor Activation Downregulates Expression of d Subunit-Containing GABAA Receptors in Cultured Hippocampal Neurons

S Activation of UTP-Sensitive P2Y2 Receptor Induces the Expression of Cholinergic Genes in Cultured Cortical Neurons: A Signaling Cascade Triggered by Ca Mobilization and Extracellular Regulated Kinase Phosphorylation Roy C. Y. Choi, Glanice K. Y. Chu, Nina L. Siow, Amanda W. Y. Yung, Lisa Y. Yung, Pinky S. C. Lee, Christopher C. W. Lo, Joseph Simon, Tina T. X. Dong, Eric A. Barnard, and Karl W...

N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands.

A series of analogues based on N-hydroxypyrazole as a bioisostere for the distal carboxylate group of aspartate have been designed, synthesized, and pharmacologically characterized. Affinity studies on the major glutamate receptor subgroups show that these 4-substituted N-hydroxypyrazol-5-yl glycine (NHP5G) derivatives are selectively recognized by N-methyl- d-aspartic acid (NMDA) receptors and...

N-methyl-D-aspartic acid receptor activation downregulates expression of δ subunit-containing GABAA receptors in cultured hippocampal neurons.

Neurosteroids are endogenous allosteric modulators of GABAA receptors (GABARs), and they enhance GABAR-mediated inhibition. However, GABARs expressed on hippocampal dentate granule neurons of epileptic animals are modified such that their neurosteroid sensitivity is reduced and δ subunit expression is diminished. We explored the molecular mechanisms triggering this GABAR plasticity. In the cult...

N-methyl-D-aspartic acid receptor structure and function.

Paraneoplastic Anti-N-Methyl-D-Aspartic Acid Receptor Encephalitis